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RECOVER: Researching COVID to Enhance Recovery

Long COVID is real. Millions of people who had COVID-19 still have symptoms lasting months or years.

We created RECOVER to understand, diagnose, prevent, and treat Long COVID and help people who are suffering.

Learn about Long COVID

The RECOVER Initiative

Millions of Americans suffer from Long COVID. This disease affects each person differently, so no single research study can provide all the answers to Long COVID for everyone. The National Institutes of Health (NIH) created the RECOVER Initiative to find answers across many different types of research studies.

RECOVER brings together clinicians, scientists, caregivers, patients, and community members to understand, diagnose, prevent, and treat Long COVID. We’ve created the world’s most comprehensive and diverse group of Long COVID study participants.

We’re learning about Long COVID and testing different treatments. We’re sharing our research, quickly learning from it, adapting, and constantly refocusing our efforts to ease suffering for millions of people.

Together, we are working to understand, diagnose, prevent, and treat Long COVID.

Learn About RECOVER

Explore RECOVER’s progress and find out how to get involved:

RECOVER Research

Each RECOVER research team can use all RECOVER findings, data, and biosamples (small amounts of blood, saliva, and tissue, also known as biospecimens) to inform and improve their study. This way, we can learn more quickly about this complex condition and better understand, diagnose, prevent, and treat Long COVID.

Treatments

Researchers study drugs, medical devices, or other approaches that may help relieve Long COVID symptoms.

Patient Health Over Time

Researchers study the health and symptoms of thousands of participants over several years. No treatments or medicines are provided.

Researchers study people who have died after having COVID, including people who did not have Long COVID.

Researchers use RECOVER data and biosamples (biospecimens) to answer new and important questions about Long COVID.

Graphic showing the interaction of the RECOVER Initiative’s research studies and information exchange.

All Data Shared.

Four concepts interact to integrate the information gained from the groups into the overall RECOVER Initiative.

Treatments.

This includes information from clinical trials.

Patient Healthcare Over Time.

This includes information from observational cohort studies, autopsy studies, and ancillary studies.

Clinical Science.

This includes information from pathobiology studies.

Real World Data.

This includes information from electronic health record (EHR) studies and the Digital Health Program.

Clinical Science

Researchers study biosamples (biospecimens) from people with and without Long COVID to understand how COVID affects different body systems.

Real World Data

Researchers study millions of digital medical records, called EHRs, to understand changes over time, learn who may have Long COVID, and learn how to treat or prevent it.

Large circle with four small circles inside illustrating the RECOVER project's Research Components and Information Exchange. There are arrows connecting each of the four components: Treatments, Patient Health Over Time, Clinical Science, and Real World Data. The large circle communicates that all data is shared between the different types of RECOVER research.

RECOVER Research

Each RECOVER research team can use all RECOVER findings, data, and biosamples (small amounts of blood, saliva, and tissue, also known as biospecimens) to inform and improve their study. This way, we can learn more quickly about this complex condition and better understand, diagnose, prevent, and treat Long COVID.

Treatments

Researchers study drugs, medical devices, or other approaches that may help relieve Long COVID symptoms.

Patient Health Over Time

Researchers study the health and symptoms of thousands of participants over several years. No treatments or medicines are provided.

Researchers study people who have died after having COVID, including people who did not have Long COVID.

Researchers use RECOVER data and biosamples (biospecimens) to answer new and important questions about Long COVID.

Clinical Science

Researchers study biosamples (biospecimens) from people with and without Long COVID to understand how COVID affects different body systems.

Real World Data

Researchers study millions of digital medical records, called EHRs, to understand changes over time, learn who may have Long COVID, and learn how to treat or prevent it.

All Data Shared

RECOVER shares the data between the different types of research to understand, diagnose, prevent, and treat Long COVID.

RECOVER Enrollment

Observational Cohort Studies

Enrollment Complete

Adult Cohort

Pediatric Cohort

Pregnancy Cohort

Explore the study overview

How Can I Participate?

Join a clinical trial

RECOVER-Treating Long COVID (RECOVER-TLC) is now enrolling participants in the next phase of RECOVER clinical trials. The REVERSE-LC study will test the safety and effectiveness of the drug barcitinib to help improve thinking and memory problems and reduce fatigue.

Learn about REVERSE-LC


Provide feedback on the design of clinical trials

RECOVER-TLC invites members of the Long COVID community to review and comment on draft protocol synopses for upcoming clinical trials. These documents summarize the questions the study will investigate, how researchers will look for answers, and who is eligible to participate. Feedback will be accepted from registered public commenters during announced public comment periods. To receive notifications, gain access to drafts, and submit feedback, register through the RECOVER-TLC Collaborator Portal.

Become a commenter


Share ideas for Long COVID treatment

RECOVER-TLC is accepting possible treatment ideas for symptoms of Long COVID. To date, more than 550 drugs, medical devices, and other therapies have been submitted, and 4 treatment ideas have been selected for the first round of RECOVER-TLC trials. Patients, caregivers, healthcare providers, researchers, and others can continue submitting ideas through the RECOVER-TLC Intervention Information Request Form.

Submit a Response

Explore COVID-19 Resources

View the latest statistics about COVID-19 cases in the United States.
Find information to help reach communities hit hardest by the pandemic.
Find information to help treat patients.
Encuentre recursos en español, sobre el COVID-19.