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Sharing science to find answers
Find RECOVER Publications
Researchers within the RECOVER Initiative share their progress to understand, treat, and prevent Long COVID through research publications. Follow the latest science from RECOVER’s research studies below.
Visit the Research Summaries page to learn about RECOVER’s Long COVID research in a format that’s easy to understand.
Abstract: Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults. Observations: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is… Continue reading
Authors: Rachel S Gross, Tanayott Thaweethai, Erika B Rosenzweig, James Chan, Lori B Chibnik, Mine S Cicek, Amy J Elliott, Valerie J Flaherman, Andrea S Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L Jernigan, Elizabeth W Karlson, Stuart D Katz, Patricia A Kinser, Lawrence C Kleinman, Michelle F Lamendola-Essel, Joshua D Milner, Sindhu Mohandas, Praveen C Mudumbi, Jane W Newburger, Kyung E Rhee, Amy L Salisbury, Jessica N Snowden, Cheryl R Stein, Melissa S Stockwell, Kelan G Tantisira, Moriah E Thomason, Dongngan T Truong, David Warburton, John C Wood, Shifa Ahmed, Almary Akerlundh, Akram N Alshawabkeh, Brett R Anderson, Judy L Aschner, Andrew M Atz, Robin L Aupperle, Fiona C Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C Bind, Amanda L Bogie, Tamara Bradford, Natalie C Buchbinder, Elliott Bueler, Hülya Bükülmez, B J Casey, Linda Chang, Maryanne Chrisant, Duncan B Clark, Rebecca G Clifton, Katharine N Clouser, Lesley Cottrell, Kelly Cowan, Viren D'Sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Audrey Dionne, Kirsten B Dummer, Matthew D Elias, Shari Esquenazi-Karonika, Danielle N Evans, E Vincent S Faustino, Alexander G Fiks, Daniel Forsha, John J Foxe, Naomi P Friedman, Greta Fry, Sunanda Gaur, Dylan G Gee, Kevin M Gray, Stephanie Handler, Ashraf S Harahsheh, Keren Hasbani, Andrew C Heath, Camden Hebson, Mary M Heitzeg, Christina M Hester, Sophia Hill, Laura Hobart-Porter, Travis K F Hong, Carol R Horowitz, Daniel S Hsia, Matthew Huentelman, Kathy D Hummel, Katherine Irby, Joanna Jacobus, Vanessa L Jacoby, Pei-Ni Jone, David C Kaelber, Tyler J Kasmarcak, Matthew J Kluko, Jessica S Kosut, Angela R Laird, Jeremy Landeo-Gutierrez, Sean M Lang, Christine L Larson, Peter Paul C Lim, Krista M Lisdahl, Brian W McCrindle, Russell J McCulloh, Kimberly McHugh, Alan L Mendelsohn, Torri D Metz, Julie Miller, Elizabeth C Mitchell, Lerraughn M Morgan, Eva M Müller-Oehring, Erica R Nahin, Michael C Neale, Manette Ness-Cochinwala, Sheila M Nolan, Carlos R Oliveira, Onyekachukwu Osakwe, Matthew E Oster, R Mark Payne, Michael A Portman, Hengameh Raissy, Isabelle G Randall, Suchitra Rao, Harrison T Reeder, Johana M Rosas, Mark W Russell, Arash A Sabati, Yamuna Sanil, Alice I Sato, Michael S Schechter, Rangaraj Selvarangan, S Kristen Sexson Tejtel, Divya Shakti, Kavita Sharma, Lindsay M Squeglia, Shubika Srivastava, Michelle D Stevenson, Jacqueline Szmuszkovicz, Maria M Talavera-Barber, Ronald J Teufel, Deepika Thacker, Felicia Trachtenberg, Mmekom M Udosen, Megan R Warner, Sara E Watson, Alan Werzberger, Jordan C Weyer, Marion J Wood, H Shonna Yin, William T Zempsky, Emily Zimmerman, Benard P Dreyer,
Abstract: BACKGROUNDPersistent cough and dyspnea are prominent features of post-acute sequelae of SARS-CoV-2 (also termed 'Long COVID'); however, physiologic measures and clinical features associated with these pulmonary symptoms remain poorly defined. Using longitudinal pulmonary function testing (PFTs) and CT imaging, this study aimed to identify the characteristics and determinants of pulmonary Long COVID.METHODSThis single-center retrospective study included 1,097 patients with clinically defined… Continue reading
Authors: Michael John Patton, Donald Benson, Sarah W Robison, Dhaval Raval, Morgan L Locy, Kinner Patel, Scott Grumley, Emily B Levitan, Peter Morris, Matthew Might, Amit Gaggar, Nathaniel Erdmann
Caution: Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Abstract: Preventing and treating post-acute sequelae of SARS-CoV-2 infection (PASC), commonly known as Long COVID, has become a public health priority. In this study, we examined whether treatment with Paxlovid in the acute phase of COVID-19 helps prevent the onset of PASC. We used electronic health records from the National Covid Cohort Collaborative (N3C) to define a cohort of 426,352 patients who had COVID-19 since April 1, 2022, and were eligible for Paxlovid treatment due to risk for progression to… Continue reading
Authors: Alexander Preiss, Abhishek Bhatia, Leyna V Aragon, John M Baratta, Monika Baskaran, Frank Blancero, M Daniel Brannock, Robert F Chew, Iván Díaz, Megan Fitzgerald, Elizabeth P Kelly, Andrea Zhou, Thomas W Carton, Christopher G Chute, Melissa Haendel, Richard Moffitt, Emily Pfaff
Chen, Y; Zhang, D; Zhang, B; et. al., Research Square
Caution: Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
Abstract: Racial/ethnic differences are associated with the potential symptoms and conditions of post-acute sequelae SARS-CoV-2 infection (PASC) in adults. These differences may exist among children and warrant further exploration. We conducted a retrospective cohort study for children and adolescents under the age of 21 from the thirteen institutions in the RECOVER Initiative. The cohort is 225,723 patients with SARS-CoV-2 infection or COVID-19 diagnosis and 677,448 patients without SARS-CoV-2 infection… Continue reading
Abstract: The coronavirus disease 2019 (COVID-19) pandemic has caused significant medical, social, and economic impacts globally, both in the short and long term. Although most individuals recover within a few days or weeks from an acute infection, some experience longer lasting effects. Data regarding the postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection (PASC) in children, or long COVID, are only just emerging in the literature. These symptoms and conditions may reflect… Continue reading
Authors: Suchitra Rao, Rachel S Gross, Sindhu Mohandas, Cheryl R Stein, Abigail Case, Benard Dreyer, Nathan M Pajor, H Timothy Bunnell, David Warburton, Elizabeth Berg, Jonathan B Overdevest, Mark Gorelik, Joshua Milner, Sejal Saxena, Ravi Jhaveri, John C Wood, Kyung E Rhee, Rebecca Letts, Christine Maughan, Nick Guthe, Leah Castro-Baucom, Melissa S Stockwell
Keywords: Child; Humans; Autoimmune Diseases; COVID-19/complications/epidemiology; Disease Progression; Observational Studies as Topic; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Systemic Inflammatory Response Syndrome; United States
Abstract: Long COVID may occur in at least 10% of subjects recovering from severe acute respiratory syndrome coronavirus-2 (SARS-Co-V-2) infection and is often associated with debilitating symptoms. Among the organ systems that might be involved in its pathogenesis, the respiratory and cardiovascular systems may be central to common complaints seen in survivors of COVID including fatigue, dyspnea, chest pain, cough, and exercise intolerance. Understand the exact symptomatology, causes, and effects of… Continue reading
Authors: RECOVER Cardiopulmonary Committee, Franz Rischard, Natasha Altman, Jacqueline Szmuszkovicz, Frank Sciurba, Erika Berman-Rosenzweig, Simon Lee, Sankaran Krishnan, Ngan Truong, John Wood, Aloke V Finn
Keywords: Cardiopulmonary Exercise Testing (CPET); Interstitial Lung Disease (ILD); Multisystem Inflammatory Syndrome in Children (MIS-C); Postacute Sequelae of COVID-19 (PASC); Post-COVID-19 Interstitial Lung Disease (PC-ILD); Pulmonary Function Testing (PFT); Postural Orthostatic Tachycardia Syndrome (POTS); Researching COVID to Enhance Recovery (RECOVER)
Abstract: Vaccination reduces the risk of acute COVID-19 in children, but it is less clear whether it protects against long COVID. We estimated vaccine effectiveness (VE) against long COVID in children aged 5-17 years. This retrospective cohort study used data from 17 health systems in the RECOVER PCORnet electronic health record (EHR) Program for visits after vaccine availability. Conditional logistic regression was used to estimate VE against long COVID with matching on age group (5-11, 12-17) and time… Continue reading
Authors: Hanieh Razzaghi, Christopher B Forrest, Kathryn Hirabayashi, Qiong Wu, Andrea Allen, Suchitra Rao, Yong Chen, H Timothy Bunnell, Elizabeth A Chrischilles, Lindsay G Cowell, Mollie R Cummins, David A Hanauer, Miranda Higginbotham, Benjamin D Horne, Carol R Horowitz, Ravi Jhaveri, Susan Kim, Aaron Mishkin, Jennifer A Muszynski, Susanna Naggie, Nathan M Pajor, Anuradha Paranjape, Hayden T Schwenk, Marion R Sills, Yacob G Tedla, David A Williams, Charles Bailey
Abstract: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or organ dysfunction after the acute phase of infection, termed Post-Acute Sequelae of SARS-CoV-2 (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are poorly understood. The objectives of the Researching COVID to Enhance Recovery (RECOVER) tissue pathology study (RECOVER-Pathology) are to: (1) characterize prevalence and types of organ injury/disease and pathology occurring with PASC… Continue reading
Authors: Andrea B Troxel, Marie-Abele C Bind, Thomas J Flotte, Carlos Cordon-Cardo, Lauren A Decker, Aloke V Finn, Robert F Padera, R Ross Reichard, James R Stone, Natalie L Adolphi, Faye Victoria C Casimero, John F Crary, Jamie Elifritz, Arline Faustin, Saikat Kumar B Ghosh, Amanda Krausert, Maria Martinez-Lage, Jonathan Melamed, Roger A Mitchell, Barbara A Sampson, Alan C Seifert, Aylin Simsir, Cheryle Adams, Stephanie Haasnoot, Stephanie Hafner, Michelle A Siciliano, Brittany B Vallejos, Phoebe Del Boccio, Michelle F Lamendola-Essel, Chloe E Young, Deepshikha Kewlani, Precious A Akinbo, Brendan Parent, Alicia Chung, Teresa C Cato, Praveen C Mudumbi, Shari Esquenazi-Karonika, Marion J Wood, James Chan, Jonathan Monteiro, Daniel J Shinnick, Tanayott Thaweethai, Amber N Nguyen, Megan L Fitzgerald, Alice A Perlowski, Lauren E Stiles, Moira L Paskett, Stuart D Katz, Andrea S Foulkes,
